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王 智教授 博士生导师
2017-10-25 09:43   审核人:

王 智

教授 博士生导师

wangzhi@jlu.edu.cn

13504429501;QQ64506919

一、个人介绍:

学历:

1992年9月-1996年7月 理学学士

1996年9月-1999年7月 理学硕士

2000年9月-2003年12月 理学博士

任职经历:

1999年9月-2001年9月 吉林大学 助教

2001年9月-2006年9月 吉林大学 讲师

2006年9月-2011年12月 吉林大学 副教授

2011年12月-至今 吉林大学 教授

2012年-至今 吉林大学 博士导师

二、研究方向:

1. 非常规反应介质中的酶学研究

酶在有机溶剂或离子液体中催化反应的研究

2. 生物催化与生物转化

手性化合物的酶促拆分以及天然产物的酶法修饰

3. 酶的分子识别

利用计算机以及生物物理学手段阐明酶分子的催化机制

4. 酶工程

利用物理或化学手段提高酶分子的催化性能

5. 纳米生物反应器

制备新型的纳米级别的固定化酶或模拟酶

三、承担项目

1. 国家自然科学基金 设计、构建和改造用于手性拆分1,1,1-三氟代-2-辛醇的模块酶,项目批准号:31070708,2011.1-2013.12

2. 吉林省自然科学基金 松针提取物中影响运动能力的有效化学成分研究,项目批准号:201115038,(2011.1-2013.12)

3. 吉林省自然科学基金 超声辅助非水介质中布洛芬的酶促拆分及其作用机制的研究,项目批准号:20140101141JC,(2014.1-2016.12)

四、文章

已经发表的文章:

(1) An Baiyi; Xie Xiaona; Xun Erna; Wang Ren; Li Chunyuan; Sun Ruoxi; Wang Lei; Zhi Wang(联系人), Ultrasound-promoted lipase-catalyzed enantioselective transesterification of (R, S)-glycidol, 2011, Chemical Research in Chinese Universities, 2011, 25(7): 845-849 IF:0.252

(2) Zhao Dan-tong, Xun Er-na, Wang Jia-xin, Wang Ren, Wei Xiao-fei, Wang Lei, Zhi Wang(联系人), Enantioselective esterification of ibuprofen by a novel thermophilic biocatalyst: APE1547, Biotechnology and Bioprocess Engineering, 2011, 16(4): 638-644 IF:1.003

(3) Rui Tian, Chun-Hua Yang, Xiao-Fei Wei, Er-Na Xun, Ren Wang, Shu-Gui Cao, Zhi Wang(联系人), and Lei Wang, Optimization of APE1547-catalyzed Enantioselective Transesterification of (R/S)-2-methyl-1-butanol in an Ionic Liquid, Biotechnology and Bioprocess Engineering 2011, 16: 337-342 IF: 1.003

(4) Wang, Xiaodan; Zhang, Bo; Xu, Duo; Gao, Jinlan; Wang, Linfang; Zhi Wang; *Shan, Yaming; Yu, Xianghui, Purification, crystallization and preliminary X-ray crystallographic analysis of the CIDE-N domain of Fsp27, Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 2012, 68: 1529-1533 IF: 0.506

(5) Hong Zhuang, Zhi Wang, Jiaxin Wang, Hong Zhang, Erna Xun, Ge Chen, HongYue, Ning Tang,Lei Wang, Synthesis of triptorelin lactate catalyzed by lipase in nonaqueous media, Int. J. Mol. Sci., 2012, 13: 9971-9979 IF:2.464

(6) Yanfu Huan, Erna Xun, Lina Xue, Shigang Wei, Jiaxin Wang, and Zhi Wang(联系人), Potential for pH Monitoring the Enzyme-Catalyzed Hydrolysis of Esters with a Novel Nano-Engineered Fluorescent Probe, Sensor Letters, 2012, 10: 947-952 IF:0.517

(7) Hong Zhang, Erna Xun, Jiaxin Wang, Ge Chen, Tiexin Cheng, Zhi Wang(联系人), Tengfei Ji, Lei Wang, Immobilization of Laccase for Oxidative Coupling of Trans-Resveratrol and Its Derivatives, Int. J. Mol. Sci., 2012, 13: 5998-6008 IF:2.464

(8) Dahai Yu, Dongxiao Ma, Zhi Wang, Yu Wang, Yang Pan, Xuexun Fang, Microwave-assisted enzymatic resolution of (R,S)-2-octanol in ionic liquid, Process Biochemistry, 2012, 47(3): 479–484 IF:2.414

(9) Xie Xiao-na, Zhang Chun-li, Xun Er-na, Wang Jia-xin, Zhang Hong, Wang Lei, Zhi Wang(联系人), Acylation of quercetin using a novel thermophilic esterase as biocatalyst, Chemical Research in Chinese Universities, 2012, 28(2): 225-229 IF:0.735

(10) Xun Er-na, Lv Xiao-li, Kang Wei, Wang Jia-xin, Zhang Hong, Wang Lei, Zhi Wang(联系人), Immobilization of Pseudomonas fluorescens Lipase onto Magnetic Nanoparticles for Resolution of 2-Octanol, Applied Biochemistry and Biotechnology, 2012, 168: 697-707 IF:1.893

(11) Wang Feng, Zhang Hong, Wang Jiaxin, Ge Chen, Fang Xuedong, Zhi Wang(联系人), Wang Lei, Ultrasound irradiation promoted enzymatic transesterification of (R/S)-1-chloro- 3-(1- naphthyloxy)-2-propanol, Molecules 2012, 17: 10864-10874 IF:2.428

(12) Mengxing Dong, Zhuofu Wu, Ming Lu, Zhi Wang and Zhengqiang Li, Combining the Physical Adsorption Approach and the Covalent Attachment Method to Prepare a Bifunctional Bioreactor, Int. J. Mol. Sci. 2012, 13: 11443-11454 IF:2.464

(13) Qinghua Miao, Suping Li, Siyuan Han, Zhi Wang(联系人), Yan Wu, Guangjun Nie, Construction of hydroxypropyl-b-cyclodextrin copolymer nanoparticles and targeting delivery of paclitaxel, J Nanopart Res. 2012, 14: 1043 IF: 2.278

(14) Shanshan Li, Zhuofu Wu, Ming Lu, Zhi Wang and Zhengqiang Li, Improvement of the Enzyme Performance of Trypsin via Adsorption in SBA-15: Hydrolysis of BAPNA, Molecules 2013, 18: 1138-1149 IF: 2.095

(15) Erna Xun, JiaxinWang, Hong Zhang, Ge Chen, Hong Yue,Jimin Zhao, Lei Wang and Zhi Wang(联系人), Resolution of N-hydroxymethyl Vince Lactam Catalyzed by Lipase in Organic Solvent, Journal of Chemical Technology & Biotechnology, 2013, 88(5): 904–909 IF:2.494 (16) Zecheng Yang, Xuedun Niu, Xuedong Fang, Ge Chen, Hong Zhang, Hong Yue, Lei Wang, Dantong Zhao and Zhi Wang(联系人), Enantioselective Esterification of Ibuprofen under Microwave Irradiation, Molecules 2013, 18: 5472-5481 IF: 2.095

(17) Zhang Lei, Zhang Shitao, Zhang Xiaoping, Sun Jing, Wang Yongsen, Liu Yuelong, Xue Miaomiao, Zhi Wang, Xing Shu, Ma Junfeng, Li Wannan, Fu Xueqi, Effect of candesartan cilexetil as a sensitive and effective inhibitor os SHP-1 on insulin signaling pathway, Chem Res Chin Univ, 2013, 29(4): 730-734 IF: 1.119

(18) Wu Zhuofu, Zhi Wang, Guan Buyuan, Wang Xue, Zhang Ye, Xiao Yu, Zhi Bo, Liu Yunling, Li Zhengqiang and Huo Qisheng. Improving the properties of ?-galactosidase from Aspergillus oryzae via encapsulation in aggregated silica nanoparticles. New journal of chemistry 2013, 37: 3793-3797 IF: 3.159

(19) Xuedun Niu, Zhi Wang, Yang Li, Zijian Zhao, Jiayin Liu, Li Jiang, Haoran Xu, Zhengqiang Li,'Fish-in-Net', a Novel Method for Cell Immobilization of Zymomonas mobilis,PLOS ONE, 2013, 8(11): e79569 IF: 3.534

(20) Li Fuqiu, Zhao Dantong, Chen Ge, Zhang Hong, Yue Hong, Wang Lei, Zhi Wang(联系人), Enantioselective transesterification of N-hydroxymethyl vince lactam catalyzed by lipase under ultrasound irradiation, biocatalysis and biotransforfation, 2013, 31(6): 299-304 IF: 1.093

(21) Zhuofu Wu, Wenzhao Li, Zhi Wang, Ling Qin, Yunling Liu, Qisheng Huo and Zhengqiang Li, Resolution of 1,1,1-trifluoro-2-octanol by Pseudomonas sp. lipase encapsulated in aggregated silica nanoparticles, RSC Advances, 2014, 4, 6103-6109 IF:3.708

(22) Angela Bamesberger, Christopher Schwartz, Qiao Song, Weiwei Han, Zhi Wang and Haishi Cao, Rational design of a rapid fluorescent approach for detection of inorganic fluoride in MeCN–H2O: a new fluorescence switch based on N-aryl-1,8-naphthalimide, New J. Chem., 2014, 38, 884-888 IF:3.159

(23) Yanyan Chen, Dejun Sun, Yulai Zhou, Liping Liu, Weiwei Han, Baisong Zheng, Zhi Wang and Zuoming Zhang, Cloning, Expression and Characterization of a Novel Thermophilic Polygalacturonase from Caldicellulosiruptor bescii DSM 6725, Int. J. Mol. Sci. 2014, 15, 5717-5729 IF:2.339

(24) Wang Haoran, Wang Zhi(并列一作), Zhang Hong, Chen Ge, Yue Hong and Wang Lei, Enzyme catalytic promiscuity: asymmetric aldol addition reaction catalyzed by a novel thermophilic esterase in organic solvent, Green Chemistry Letters and Reviews, 2014, 7(2): 145–149 IF:1.216

(25) Hong Zhang, Zhi Wang(并列一作), Chunyu Wang, Haoran Wang, Tiexin Cheng, Lei Wang, A novel method for the enamination of 1,3-dicarbonyl compounds catalyzed by laccase in water, RSC advance, 2014,4, 19512-19515 IF:3.708

(26) Zhi Wang(并列一作), Chun-Yu Wang, Hao-Ran Wang, Hong Zhang, Ya-Lun Su, Teng-Fei Ji, Lei Wang, ,Lipase-catalyzed Knoevenagel condensation between α,β-unsaturated aldehyde and active methylene compound, Chinese Chemical Letters, 2014, 25(5): 802–804 IF:1.178

(27) Fengjuan Yang, Zhi Wang(并列一作), Haoran Wang, Hong Zhang, Hong Yue, Lei Wang, Enzyme catalytic promiscuity: Lipase catalyzed synthesis of substituted 2H-chromenes by three-component reaction, RSC advance, 2014,4, 25633-25636 IF:3.708

(28) Haoran Wang, Zhi Wang(并列一作), Chunyu Wang, Fengjuan Yang, Hong Zhang, Hong Yue, Lei Wang, Lipase catalyzed synthesis of 3, 3’ - (arylmethylene) bis (2- hydroxynaphthalene - 1, 4 - dione), RSC advance, 2014, 4, 35686-35689 IF:3.708

(29) Zhuofu Wu, Xiang Li, Fuguang Li, Hong Yue, Chengyan He, Feng Xie and Zhi Wang (联系人), Enantioselective transesterification of (R,S)-2-pentanol catalyzed by a new flower-like nanobioreactor, RSC Adv., 2014, 4 (64), 33998 – 34002 IF:3.708

(30) Zhao Dantong, Yue Hong, Chen Ge, Jiang Liyan, Zhang Hong, Zhi Wang(联系人) and Liu Guangchun, Enzymatic resolution of ibuprofen in organic solvent under ultrasound irradiation, Biotechnology and Applied Biochemistry, 2014,61(6): 655-659 IF: 1.322

(31) Fengjuan Yang, Haoran Wang, Liyan Jiang, Hong Yue, Hong Zhang, Zhi Wang(联系人), Lei Wang, A green and one-pot synthesis of benzo[g]chromene derivatives through a multi-component reaction catalyzed by lipase, RSC Adv., 2015,5, 5213-5216 IF:3.708

(32) Zhang Lei, Liu Peng, Xie Xiaona, Wang Deli, Sun Jing, Wang Yongsem, Zhi Wang, Xing Shu, Ma Junfeng, Li Wannan, Fu Xueqi, An extract of Perilla stem inhibits Src homology phosphatase-1 (SHP-1) and influences insulin signaling, Pak. J. Pharm. Sci., 2015,.28(2): 421-424 IF: 0.95

(33) Erna Xun, Zhi Wang, Jimin Zhao, Jixun Guo, Kinetic Resolution of (R, S)-2-(2-Chloro-1-hydroxyethyl) thiophene via Immobilizing Lipase from Alcaligenes sp. onto Magnetic Nanoparticles, Journal of Chemical Technology and Biotechnology, 2015, 90(3): 492–499 IF: 2.494

(34) Liyan Jiang, Xiaona Xie, Hong Yue, Zhuofu Wu, Haoran Wang, Fengjuan Yang, Lei Wang, Zhi Wang(联系人), Highly efficient and regioselective acylation of arbutin catalyzed by lipase from Candida sp., Process biochemistry, 2015, 50: 789-792 IF: 2.524

(35 )Ning Liu, Lei Wang, Zhi Wang, Liyan Jiang, Zhuofu Wu, Hong Yue and Xiaona Xie, Microwave-assisted resolution of α-lipoic acid catalyzed by an ionic liquid co-lyophilized lipase, molecules, 2015, 20, 9949-9960 IF:2.465

(36) Fengjuan Yang, Zhi Wang (并列一作), Haoran Wang, Chunyu Wang, Lei Wang, An efficient condensation of substituted salicylaldehyde and malononitrile catalyzed by lipase under microwave irradiation,RSC Adv., 2015, 5, 57122-57126 IF:3.289

(37) Fengjuan Yang, Zhi Wang(并列一作), Xiaowen Zhang, Liyan Jiang, Yazhuo Li and Lei Wang, A green chemo-enzymatic process for the synthesis of azoxybenzenes, ChemCatChem 2015, 7, 3450 –3453 IF:4.724

六、课题组成员及合作伙伴

王浩然 罗赫然 王佳欣 荀二娜 岳 宏 张 博 张 弘 杨凤娟

姜丽艳 阎国栋 吴卓夫 杨泽成 谢晓娜 郑 璐 崔秀云 张予心

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